Research in BioClinicum

In BioClinicum, research groups from Karolinska Institutet are gathered within six research themes with preclinical research in focus. The research groups are affiliated with Karolinska University Hospital's medical units and collaborate with the hospital to translate new research results into healthcare.

BioClinicum Research Themes

BioClinicum is home to almost 100 research groups where each group belongs to one of six Research Themes depending on the field of focus.

Aging

Research Theme Aging studies neurodegenerative diseases such as Alzheimer's disease as well as damages to the brain and spinal cord.
Research theme leader: Helena Karlström

Research Groups

The Andre Fisahn lab studies mechanisms of neuronal synchronization and functional dynamics of neuronal networks that form the basis for our brain’s cognitive ability.

The Bengt Winblad lab performs research on clinical evaluation and treatment of dementia, with special focus on Alzheimer disease. 

The Caroline Graff lab studies the genetics and neuropathology of neurodegenerative diseases with focus on Alzheimer disease, Frontotemporal lobar degeneration (FTLD) and FTLD associated with amyotrophic lateral sclerosis.

The Erik Sundström lab aims to develop cell therapy for spinal cord injury, in particular to treat post-traumatic syringomyelia.

The Helena Karlström lab focuses on CADASIL, the most common familial form of small vessel disease. The aim is to improve our understanding of the molecular mechanisms involved in the condition and to develop novel therapeutics.

The Jaan-Olle Andressoo lab aims to develop novel therapeutic approaches to be used in treatments of currently incurable neurodegenerative diseases such as Alzheimer disease. 

The Lars Tjernberg lab focuses on elucidating, in molecular and subcellular detail, which pathways lead to Alzheimer disease.

The Linus Jönsson lab studies health economics, analysing costs and cost effectiveness in care of diseases with associated societal costs, mainly Alzheimer disease and other dementias.

The Maria Ankarcrona lab have the main objective to understand the mechanisms whereby cells degenerate in Alzheimer disease with focus on the role of mitochondria and organelle interplay.

The Marianne Schultzberg lab studies the role of inflammatory cytokines in the brain in physiological and pathophysiological conditions, in particular analysing the possibility to target glial cells in treatment of Alzheimer disease and other neurodegenerative disorders.

The Per Nilsson lab studies how dysfunctional autophagy may lead to Alzheimer disease. The aim is to find new treatment strategies.

The Silvia Maioli lab is focused on understanding the biological mechanisms behind risk factors for Alzheimer disease and aging.

Cancer

Research Theme Cancer studies various cancer diseases. The main aim is to identify new treatment strategies and to develop new methods for diagnosis, prognosis and precision medicine.
Research theme leader: Andreas Lundqvist

Research Groups

The Andreas Lundqvist lab aims to understand mechanisms of immune escape in solid tumors.

The Anders Österborg and Håkan Mellstedt lab aim to develop and optimize chemotherapy-free precision medicine for patients with B cell malignancies such as chronic lymphocytic leukemia and B cell lymphomas.

The Anita Göndör lab studies the interplay between circadian 3D genome organization and metabolism in complex diseases.

The Arne Östmans lab studies the microenvironment in tumours with focus on the paracrine interplay between malignant cells, fibroblasts, vascular cells and immune cells. 

The Swedish Childhood Tumour Biobank is a national sample collection and genomic characterisation initiative of pediatric solid tumours for research purpose.

The Catharina Larsson lab aims to explain tumor initiation and malignification in endocrine organs focusing on genetic predisposing, initiating and acquired events and their cellular effects and influence of the natural course of the disease.

The Cecilia Söderberg Naucler lab studies microbial pathogenesis.

The Georgios Rassidakis lab studies lymphomas and leukemia with focus on immunological anti-tumor mechanisms.

The Johan Hansson lab is a translational research group aiming to improve prevention as well as treatment of malignant melanoma.

The John Inge Johnsen and Per Kogner lab consists of four research groups that all perform research to unveil the molecular landscape of malignant and corresponding non-malignant cells within the childhood neural cancers, neuroblastomas and medulloblastoma, and to apply a translational approach to identify druggable targets that can be transferred into new treatment options for children with these diseases. 

The Jonas Bergh lab performs clinical/translational/preclinical breast cancer studies in order to better understand and predict an individual patient's unique drug sensitivity, improve breast cancer survival and avoid treatment-related toxicity.

The Katja Pokrovskaja labs aim is to find novel therapeutic approaches to overcome primary and secondary resistance to anti-cancer therapy.

The Klas Wiman lab performs research in molecular cell biology, tumor biology, and novel cancer therapy. The main focus lies on understanding the normal function and regulation of the tumour supressor p53.

The Lars Holmgren labs reserach is focused on understanding the mechanisms by which blood vessels are established.

The Lars Ährlund-Richter lab

The Leonard Girnita labs focus lies on functional, diagnostic and therapeutic implications for cancer. This is done by studying the cross-talk between the receptor tyrosine kinases and G protein-coupled receptors. 

The Linda Lindström lab studies breast cancer and the specific patient and tumor characteristics required to enable the cancer tumor to gain early or late metastatic capacity, in the end responsible for virtually all cancer-related death.

The Martin Enge lab pursues projects focusing on clonal evolution, gene regulation and cell interaction in cancer using novel single-cell multiomics methodology.

The Malin Wickström lab studies the molecular mechanisms leading to the  development of the childhood cancer Neuroblastoma.

The Monica Nistér lab studies cellular and molecular pathology.

The Ninib Baryawnos lab is part of Per Kogners reaserach team and tries to solve problems that limit the ability of cancer therapy to be used more effectively against deadly forms of pediatric cancers and adult cancers. 

The Olle Larsson lab studies the insulin-like growth factor 1 receptor (IGF-1R) and its role in malignant cell growth. Their research attempts to identify mechanisms responsible for the critical roles of IGF-1R in cancer as well as to develop selective anti-IGF-1R agents for tumor treatment.

The Pär Nordlund lab has developed the Thermal Shift Assay (CETSA), the first broadly applicable method to study interactions with proteins in living cells. By using this method they aim to gain knowledge about cellular mechanisms in cancer, discover novel drug targets and find new biomarkers for improved cancer therapy.

The Rolf Kiessling lab studies how immunotherapy can be used for activating and re-directing the body's own immune system to fight and prevent cancer.

The Simon Ekman lab focuses on thoracic oncology, and includes both clinical, translational and preclinical studies. They aim to find new treatment targets and biomarkers that are important for prognosis and treatment response, especially in the areas of lung cancer.

The Sten Nilsson lab

The Thuy Tran lab focuses on the development of radiotracers for precision diagnostics, therapy and monitoring of diseases, with the emphasis in oncological diseases.

The Tina Dalianis lab studies human papillomaviruses and specific markers for tailored and targeted therapy of head and neck cancer and childhood cancer.

The Xu Dawei lab 

The Yvonne Brandberg lab focuses on psycho-oncology, i.e. behavioral aspects of cancer prevention, psychosocial reactions to cancer treatment as well as prevention in high-risk groups, effects of cancer treatment, satisfaction and quality of life in clinical trials and development of questionnaires.

Cardiovascular

Research Theme Cardiovascular focuses on understanding the mechanisms related to heart attack, stroke, aneurysm, heart failure, thromboembolism, metabolism, inflammatory disease and diabetes. They also participate in many translational networks with the aim of improving treatment outcomes.
Research theme leader: Peder Olofsson

Research Groups

The Anneli Björklund lab studies diabetes at the Unit for Experimental and Clinical Neuroendocrinology.

The Francesco Cosentino lab focus on the molecular and cellular processes underpinning vascular and cardiac dysfunction in the context of obesity and diabetes. 

The John Pernow lab aims to explore novel mechanisms behind the progression of atherosclerosis and to develop new therapeutic strategies to reduce the risk of myocardial infarction.

The Jovan Antovic lab's area of interests are microparticles and cross-talk between coagulation and inflammation as well as laboratory diagnosis of heparin induced thrombocytopenia and markers of thrombin generation. 

The Lars Maegdefessel lab is focused on the therapeutic and biomarker potential of non-coding RNAs in cardiovascular disease and its underlying mechanisms, such as atherosclerosis, aneurysm formation, inflammation, and thrombosis. 

The Ljubica Matic lab works within the field of vascular surgery and studies atherosclerosis.

The Peder Olofsson lab studies how the nervous system regulates immunological mechanisms.

The Per Eriksson lab aims to gain insights regarding the clinical course and predictors of outcome in aortic aneurysm, to identify biomarkers for the disease and to elucidate the etiologies and pathogenic mechanisms.

The Roland Nilsson lab specializes in detailed analysis of cellular metabolism. The aim is to get a deeper and more quantitative understanding of metabolic changes that occur in cancer cells.

The Sergiu Bogdan Catrina lab works within the the field of growth and metabolism. Special focus lies on diabetes, metabolic diseases in bones and hypothyroidism.

The Ulf Hedin lab studies the basic mechanisms involved in the development of vascular disease as well as in the response of the vessel wall to vascular interventions for limb ischemia, carotid disease, stroke and aneurysms.

Neuro

Research theme Neuro studies psychiatric and neurological diseases as well as brain and spinal cord injuries. Disease mechanisms are studied with the aim of developing better diagnostics tools and discovering new or improved treatments for brain tumors, stroke, brain and spinal cord injury, multiple sclerosis, Parkinson's disease and other movement disorders. Both research and teaching are conducted in close collaboration with the clinics at Karolinska University Hospital.
Research theme leader: Per Svenningsson

Research Groups

The Karima Chergui lab aims to identify neuronal alterations in models of Parkinson’s disease. Further, they aim to increase our understanding of the mechanisms that lead to the rapid and long-lasting antidepressant action of ketamine.

The Lars Larsson lab's work is focused on the mechanisms underlying the impaired muscle function associated with aging and primary and secondary myopathies affecting sarcomeric proteins.

The Lou Brundin lab studies the effects of inflammation on neural stem cells. Their research aims to improve the restoration and limit the injury by preservation of restorative mechanisms in the CNS.

The Mikael Svensson lab aims to develop new techniques to treat injuries or diseases of the CNS using micro-surgery and stem cell technology.

The Per Svenningsson lab studies movement disorders, particularly Parkinson’s disease, and depression. They aim to understand the molecular mechanisms underlying disease states, and to identify biomarkers and  therapeutic targets. 

The Staffan Holmin lab is engaged in clinical and translational research on a wide variety of topics centered around modern neuroimaging, nuclear medicine, and image-guided vascular interventions.

Women Children and Genetics

Research Theme Women Children and Genetics carries out translational research within the field of women's and children's health as well as various genetic conditions. Research groups within the theme focus on understanding disease mechanisms at a molecular level aiming to apply new knowledge for improved diagnoses and treatments.
Research theme leader: Kristiina Tammimies

Research Groups

The Agneta Nordenskjöld lab, Malformation Genetics studies the molecular background of congenital malformations, especially disorders of sex development (hypospadias, uncertain sex at birth) and bladder exstrophy.

The Angelica Lindén Hirschberg lab investigates basic hormonal and genetic links between metabolism and reproductive function in women with polycystic ovary syndrome, overweight/underweight, premature ovarian insufficiency and disorder of sex development (DSD).

The Anna Nilsson lab aims to examine the cellular and molecular mediators behind defective antibody-mediated immune memory (humoral immunity) after pediatric cancer treatment by using lymphoblastic leukemia (ALL) as a disease model.

The Cilla Söderhäll labs main aim is to develop molecular diagnostic and prognostic tools for clinical use, that could discriminate between preschool wheezers that will develop chronic asthma and those that will grow out of their symptoms. 

The Jan-Inge Henter lab works within the field of pediatric cancer. The group is represented by two "subgroups" in BioClinicum:

Frida Holm studies epitranscriptomic regulation and its impact on cancer stem cells involved in acute lymphoblastic leukemia.

Nikolas Herold studies pediatric oncology with a research focus on chemotherapy and immunotherapy. The aim is to develop new cancer treatments.

The Lars Sävendahl lab studies bone growth with the aim of developing methods for treating children and adolescents diagnosed with abnormal growth.

The Klas Blomgren lab developes treatment strategies for healing of brain damage in children.

Richard Rosenquist Brandell is the head of the Clinical Genetics group which investigates genetic disorders on a molecular level in a translational research setting in order to understand disease mechanisms, apply new knowledge in genetic diagnostics, improve prognosis assessment and develop new treatment strategies.

The Kristiina Tammimies lab aims to understand the genetic and molecular architecture of Neurodevelopmental disorder (NDDs), and how genetic variations affect symptoms, severity and intervention outcomes in affected individuals. Additionally, they aim at identifying molecular and cellular pathways affected by genetic and environment risk factors of NDD using neuronal cells.

The Kristina Gemzell Danielsson labs focus is to explore the basics of female reproductive sciences at the molecular level to understand fertility and its associated disorders with the intention of translating the knowledge to clinical applications. 

The Magdalena Fossum lab works within the field of Tissue Engineering in Urological Reconstructive Surgery which can be used for reconstructions of the urinary bladder, treating malformations and for reconstructive surgery after cancer therapy or traumatic injury in adults.

The NORDFERTIL Research Lab is run by Jan-Bernd Stukenborg and aims to develop procedures to preserve the future fertility and hormone function of young boys who are undergoing treatments or have disorders that may affect their long-term fertility.

The Rare Diseases group headed by Ann Nordgren and Anna Lindstrand studies rare diseases both clinically and at the molecular level to improve genetic diagnostics, increase knowledge about genotype-phenotype correlations and understand disease biology. The long-term goal is to identify biomarkers and to develop personalized therapeutics in order to improve the quality of life for individuals with rare diseases.

The Ulrika Åden lab studies brain development in children with the aim to develop strategies for critically ill newborns preventing and treating brain injury and to prevent adverse neurodevelopmental outcomes.