Reproductive Medicine and Gynecological Endocrinology at the Karolinska University Hospital, Stockholm
Within the Divison of Gynecology and reproduction of Karolinska University Hospital, the Department of Reproductive Medicine is located in a new and specially designed facility at Novum in Karolinska’s Huddinge site. The department offers a full range of different types of assisted reproductive technology treatments and it is specialized in complex investigations and advanced treatments of infertility for both males and females.
The Department of Reproductive Medicine is located at the Novum-building, Karolinska, Huddinge. The Department of Reproductive Medicine has an extensive medical education program, which includes teaching activities for both medical and graduate students as well as continued education for post-graduate fellows. The department is also an ESHRE/EBCOG accredited education centre in Reproductive Medicine for specialists of Gynecology and Obstetrics.
The Department of Reproductive Medicine includes also the Stockholm PGD center. The center began operations in 1996 in close collaboration with the Department of Clinical Genetics, which establishes and carries the genetic diagnostic tests.
Every year we perform around 1100 oocyt aspirations and transfer around 2000 fresh and frozen embryos. round 500 children are born after treatment at Karolinska´s Department of Reproductive Medicine.
In addition to assisted reproduction by In vitro fertilization with or without Intra- Cytosplasmic Sperm Injection (IVF/ICSI) methods, the program for foreign patients includes the following areas:
Preimplantation genetic diagnosis (PGD)
PGD is an alternative to traditional prenatal diagnosis and involves the diagnosis of a genetic defect in the embryos at developmental stages before implantation, which therefore requires undergoing IVF/ICSI.
The advantage of PGD compared to conventional prenatal diagnosis is that pregnancy can be initiated in the knowledge that the expected child will not suffer from the disease that is wanted to be avoided. Thus the risk of a need for abortions is thereby minimized. So far,> 300 children have been born after PGD at the Stockholm PGD centre.
The clinical program for fertility preservation was started at the department in the mid 90's and has since then been at the cutting edge of development in the area. Medical indications for fertility preservation include treatments of cancer and chronic diseases but also genetic conditions that are associated with an early loss of fertility. Patients presenting with those indications may undergo gamete storage in order to preserve their chance to have children at a later time. Ejaculated or testicular sperm, ovarian tissue and oocytes as well as embryos can be cryopreserved and stored for this purpose.
Cryopreservation of sperm
Patients scheduled to undergo gonadotoxic treatment or testicular surgery can be offered to submit sperm samples for freezing and storage at our tissue establishment
Cryopreservation of oocytes (eggs)
Patients who are planned to undergo treatments with an inherent high risk of infertility are offered the possibility to freeze eggs. Women with a steady partner, may choose to fertilize the eggs, to freeze embryos. If there is a plan for freezing of embryos (fertilized eggs), the partner has to provide a semen sample for the IVF/ICSI treatment.
Cryopreservation of ovarian tissue
Patients who are young, need to start their cancer treatment within a short period of time, or very young girls can preserve ovarian tissue. The tissue is usually retrieved during surgery using minor-invasive methods, such a laparoscopy.
Retrieving sperm by microsurgery (mdTESE)
In cases of lack of sperm cells in the ejaculate, the Department of Reproductive Medicine applies the most recent technology by retrieving sperm cells through microsurgery, the mdTESE technology. We have a good success rate with this new technology, which permits sperm retrieval in cases of lack of sperm in the ejaculate.
The outpatient clinic of highly specialized Gynecological Endocrinology is located at QD63, Karolinska, Solna. At this clinic, patient groups with disorders of sex development (DSD), chromosomal disorders including Turner syndrome, premature ovarian insufficiency, hormone-producing tumors and gynecological malformations are investigated and treated by an interdisciplinary team of gynecologist, endocrinologist, pediatrician, pediatric surgeon, psychiatrist and geneticist.
The investigations include endocrine profiles in blood and urine, karyotype and DNA analysis of specific mutations, anatomical investigation of malformations by specialized ultrasound and MRT, evaluation of bone mass and body composition with DXA. Many patients need lifelong hormonal substitution and some highly specialized corrective surgery.
The clinic is integrated with the Women's Health Research Unit, where the patient groups are included in various clinical trials aiming at developing new treatment alternatives and fertility preservation. This integrated clinic for highly specialized gynecological endocrinology and clinical research is unique.
Focus on quality
Reproductive Medicine aspires to the highest levels of quality by utilizing external quality control systems
- Accredited laboratory ISO 15189:2012 - SWEDAC
- Quality certified ISO 9001:2015 – DNV GL
- Approved EU tissue establishment – IVO
- Certified training unit for medical specialists – ESHRE/EBCOG